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Medical Policy Update for December 17, 2024

Medical Guidelines

Reason for Update

Allergy Immunotherapy (Desensitization) (PDF)

References updated. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Allergy Skin and Challenge Testing (PDF)

References updated. Specialty Matched Consultant Advisory Panel review 11/2024.  Medical Director review 11/2024.

Biochemical Markers of Alzheimer Disease and Dementia AHS – G2048 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB.  Policy Statement updated to read, “BCBSNC will provide coverage for measurement of biochemical markers of Alzheimer disease when it is determined the medical criteria or reimbursement guidelines below are met.”  Added the following to the When Covered section, “Reimbursement is allowed for measurement of amyloid beta peptides in cerebrospinal fluid in individuals with Alzheimer disease or mild cognitive impairment” and removed amyloid beta peptide from one of the examples in the When Not Covered section.  Policy Guidelines updated. Added the following PLA codes to the Billing/Coding section: 0479U and 0503U.  Also added the following CPT codes to the Billing/Coding section effective 1/1/2025: 82233, 82234, 83884, 84393, and 84394. References updated.  Medical Director review 10/2024.
Biomarker Testing for Multiple Sclerosis and Related Neurologic Diseases AHS – G2123 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Updated References. Added CPT code 83884 to Billing/Coding section, effective 1/1/2025.  Medical Director review 10/2024.

Biomarkers for Myocardial Infarction and Chronic Heart Failure AHS – G2150 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Policy Guidelines and References updated. No change to policy statement. Medical Director review 10/2024.
Bone Turnover Markers Testing AHS – G2051 (PDF)

Reviewed by Avalon 3rd quarter 2024 CAB.  Description, policy guidelines, and references updated. No change to policy statement. Medical Director review 10/2022.

Celiac Disease Testing AHS – G2043 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Description, Policy Guidelines and References sections updated. No change to policy statement. Medical Director review 10/2024.

Cervical Cancer Screening AHS – G2002 (PDF)Updated Description, Related Policies, Policy Guidelines, and References. Coverage criteria #1 edited to include immunocompromised, therefore removed immunocompromised from coverage criteria #4 and #6. Coverage criteria 1a changed from individuals under 30 to individuals of all ages. Added “high-risk” to coverage criteria 1b for clarity of appropriate testing. Edited coverage criteria #5 to add “nucleic acid” for clarity on allowed test type for high-risk HPV. Added “for individuals 65 years of age or younger” to coverage criteria #6. Medical Director review 10/2024. Added CPT code 87626 to Billing/Coding section, effective 1/1/2025.
Chromoendoscopy as an Adjunct to Colonoscopy (PDF)

Policy Guidelines and References updated. Specialty Matched Consultant Advisory Panel 11/2024. Medical Director review 11/2024.

Confocal Laser Endomicroscopy (PDF)

Description, Policy Guidelines and References updated. Specialty Matched Consultant Advisory Panel 11/2024. Medical Director review 11/2024.

Diagnostic Testing of Influenza AHS - G2119 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB.  Policy Guidelines and References updated. No change to policy statement.  Medical Director review 10/2024.

Epithelial Cell Cytology in Breast Cancer Risk Assessment AHS - G2059 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Medial Director review 10/2024. Updated policy guidelines and added references. No change to policy statement.

Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant Testing AHS – G2060 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Updated Policy Guidelines and Reference sections. When Covered and Not Covered sections edited for clarity, no change to policy statement. Medical Director review 10/2024.

Fecal Calprotectin Testing in Adults AHS – G2061 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Updated Policy Guidelines and References. The following edits were made to the When Covered and Not Covered sections for clarity: added statement “This policy is specific to individuals 18 years of age or older. Criteria below do not apply to individuals less than 18 years of age.” Removed phrase “For individuals 18 years of age or older” from all coverage criteria. No change to policy statement. Medical Director review 10/2024.
Flow Cytometry AHS – F2019 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Medical Director review 10/2024. Under “when covered” 1.f, added pre-operative to coverage criteria. Updated policy guidelines and references. Added related policies section: AHS-M2182 and AHS-2175.

Focal Treatments for Prostate Cancer (PDF)

References added. Description and Policy Guidelines updated to include irreversible electroporation. No changes to the coverage criteria. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Folate Testing AHS – G2154 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Updated Description and policy guidelines. Added references. No change to policy statement.  Medical Director review 10/2024.

Gamma-glutamyl Transferase Testing in Adults AHS – G2173 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Title changed to “Gamma-glutamyl Transferase Testing in Adults AHS-G2173”. The following edits were made to the When Covered section for clarity: added statement “This policy is specific to individuals 18 years of age or older. Criteria below do not apply to individuals less than 18 years of age.” Removed previous language specifying testing criteria is for individuals 18 years of age or older from all coverage criteria. No change to policy statement. Policy Guidelines and References updated. Medical Director review 10/2024.
Gastroesophageal Reflux Disease, Transendoscopic Therapies (PDF)

Minor edits to the Description section, References updated. Specialty Matched Consultant Advisory Panel 11/2024. Medical Director review 11/2024.

General Inflammation Testing AHS – G2155 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Updated Description, Policy Guidelines, and Reference sections. Updated Note 1 in when covered section for clarity. No change to policy statement. Medical Director review 10/2024.

Genetic Testing for Neurodegenerative Disorders AHS – M2167 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Updated Description and Reference sections. Added the following statement to the When Covered Section, “Genetic counseling is required for individuals prior to and after undergoing genetic testing for diagnostic, carrier, and/or risk assessment purposes” and removed reference to genetic counseling from any disease-specific sections.  Moved the following statement, “For guidance on preconception screening for spinal muscular atrophies, please refer to Prenatal Screening (Genetic) AHS-M2179” from the SMA section of When Covered to the Related Policies for clarity.  Updated Note 2 in When Covered section. No change to policy statement. Medical Director review 10/2024.
Genomic Testing for Hematopoietic Neoplasms AHS - M2182 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Medical Director review 10/2024. Edited and reordered coverage criteria items #2, #3 and added #7. Note edited to state 2 or more tests to reflect changes to definition of genetic panel. Updated policy guidelines and references. Added the following CPT codes to “Billing/Coding section: 88237, 88291,81450,81451, 81455, 81351, 81352, 81401, 81261, 81262, 81263.
Immunopharmacologic Monitoring of Therapeutic Serum Antibodies AHS - G2105 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Description, Policy Guidelines, and References updated. Coverage criteria combined and edited for clarity on frequency. No changes to policy statement. Medical Director review 10/2024.

In Vitro Chemoresistance and Chemosensitivity Assays AHS - G2100 (PDF)

Reviewed by Avalon Q3 2024 CAB. Medical Director review 10/2024. Updated policy guidelines and references. No change to policy statement.

Injectable Bulking Agents for the Treatment of Urinary and Fecal Incontinence (PDF)

References added. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Investigational (Experimental) Services (PDF)

Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.  No change to policy statement.

Laboratory Testing for the Diagnosis of Inflammatory Bowel Disease AHS – G2121 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Description, Policy Guidelines and References updated. Coverage criteria 2 edited and now reads “Reimbursement is not allowed for the use of diagnostic algorithm-based testing, (e.g., ibs-smart™, PredictSURE IBD™ Test, Prometheus® testing) for the diagnosis or monitoring of individuals with IBD”. Previous criteria 3 stating “Reimbursement is not allowed for genetic testing for IBD” removed. Refer to General Genetic Testing, Germline Disorders AHS M2145 regarding genetic testing for IBD. Medical Director review 10/2024. 
Measurement of Thromboxane Metabolites for ASA Resistance AHS – G2107

Policy archived with Avalon 3rd Quarter 2024 CAB.

Medical Necessity (PDF)

Medical Director Review 11/2024. Specialty Matched Consultant Advisory Panel review 11/2024. No changes to policy statement.

Metabolite Markers of Thiopurines AHS – G2115 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Description, Policy Guidelines and References updated. Code 84433 added to Billing/Coding section. Medical Director review 10/2024.

Nerve Fiber Density Testing AHS – M2112 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. References updated.  Medical Director review 10/2024.

Oral Cancer Screening and Testing AHS – G2113 (PDF)Reviewed by Avalon 3rd Quarter 2024 CAB. Description section, policy guidelines, and references updated. Updated coverage criteria to read “To establish HPV tumor status for individuals with oropharyngeal squamous cell carcinoma, reimbursement is allowed for testing for high-risk HPV with either mRNA expression testing for HPV E6/E7 or immunohistochemistry for p16 expression” for clarity. Removed CPT code 87623 from Billing/Coding section. Medical Director review 10/2024.
Pelvic Floor Stimulation as a Treatment of Urinary and Fecal Incontinence (PDF)

Reference added. Updated Policy Guidelines. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Percutaneous Tibial Nerve Stimulation for Voiding Dysfunction (PDF)

References added. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Pre-Implantation Genetic Testing AHS – M2039 (PDF)

Updated Billing/Coding section to remove PLA code 0396U.

Prenatal Screening (Genetic) AHS – M2179 (PDF)

Added PLA codes 0488U, 0489U, and 0494U to Billing/Coding section.

Prenatal Screening (Nongenetic) AHS – G2035 (PDF)Reviewed by Avalon 3rd quarter 2024 CAB. Description, Related Policies, Policy Guidelines, and References updated. Updated coverage criteria #1. and #1. D to include recommended testing type. Updated coverage criteria #1. K for clarity and consistency. Coverage criteria #2 edited for clarity and consistency. Coverage criteria #3 edited for clarity on coverage related to setting. Updated Billing/Coding section to add CPT code 87389, and remove 83020, 83021, 85048, 86701, 86702, 86703, G0432, G0433, G0435; 0167U. Medical Director review 10/2024.
Prostate Biopsy Specimen Analysis AHS – G2007 (PDF)

Reviewed by Avalon 3rd Quarter CAB. Related Policies updated. Policy Guidelines and References updated. No changes to coverage criteria. Medical Director review 11/2024.

Prostatic Urethral Lift (PDF)

Reference added. Policy Guidelines updated. When Covered section updated to change “prostate gland volume is estimated to be ≤80 cc” to read “Prostate gland volume is estimated to be ≤ 100 cc”, also removed “Prostate anatomy demonstrates normal bladder neck without an obstructive or protruding median lobe” from When Covered section.  Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Sacral Nerve Neuromodulation/Stimulation for Pelvic Floor Dysfunction (PDF)

Reference added. Description section updated. Specialty Matched Consultant Advisory Panel Review 11/2024. Medical Director review 11/2024.

Serum Testing for Evidence of Mild Traumatic Brain Injury AHS – G2151 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Updated Policy Guidelines and Reference sections. No change to policy statement. Medical Director review 10/2024.

Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver Disease AHS – G2110 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Description, Policy Guidelines and References updated. Updated the name of NAFLD in coverage criteria 1 to MASLD and now reads “In order to determine therapy, the use of multianalyte assay with algorithmic analysis for noninvasive assessment of hepatic fibrosis and necroinflammatory activity (e.g., FibroTest, also known as FibroSure, ELF) in a patient with chronic liver disease secondary to hepatitis B or C or metabolic dysfunction associated steatotic liver disease (MASLD) is considered medically necessary.” No change to policy statement. Medical Director review 10/2024.

Serum Tumor Markers for Malignancies AHS – G2124 (PDF)Reviewed by Avalon Q3 2024 CAB. Medical Director review 10/2024. Updated table in “when covered” section to include coverage criteria for carcinosarcoma for ovarian cancers, indications for CLL; workup indication for calcitonin adenocarcinoma; indications to assess disease prognosis for occult primary cancers; adjuvant treatment for gallbladder cancer; workup indication for adrenocortical carcinoma; monitoring indication lactate dehydrogenase. Updated policy guidelines and references.
Testing for Diagnosis of Active or Latent Tuberculosis AHS – G2063 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Policy Guidelines and References updated. No change to policy intent.  Updated items 3, 6, and 7 in the When Not Covered section from medical necessity to reimbursement language.  Added CPT code 87564 to Billing/Coding section, effective 1/1/2025.  Medical Director review 10/2024.

Thyroid Disease Testing AHS – G2045 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB Review. Description, Policy Guidelines, and References updated. Related policies added. Coverage criteria #1 edited to address appropriate type of thyroid function testing for all sub criteria. Updated Coverage criteria #1. A to add appropriate fT4 monitoring for those diagnosed with secondary hypothyroidism. Updated coverage criteria #1.C for clarity and added that TSH is the appropriate screening test. Coverage criteria #1.C now reads “For asymptomatic individuals who have been prescribed drugs that can interfere with thyroid function and thus who are at an increased risk for thyroid disease, TSH testing at the following intervals: i) Annually. ii) When dosage or medication changes. iii) If symptoms consistent with thyroid dysfunction develop”. Updated Coverage criteria #1. D to clarify that TSH is the appropriate marker. Added new coverage criteria #1. E that reads “One-time TSH screening: i) For asymptomatic individuals at high risk for thyroid disease due to: (a) Personal or family history of thyroid dysfunction. (b) Personal or family history of type 1 diabetes or other autoimmune disease. ii) For individuals with disease or neoplasm of the thyroid or other endocrine glands. iii) For individuals with chronic or acute urticaria. iv) For pediatric individuals diagnosed with short stature. v) For pediatric individuals with a clinical finding of failure-to-thrive.” Updated coverage criteria #1. F to add TSH with reflex fT4 and fT3 when initial result is abnormal, as appropriate marker testing. Added new Coverage criteria #1. G that reads “For individuals with hypothalamic-pituitary disease, monitoring of TSH and fT4: i) Biannually for individuals less than 18 years of age. ii) Annually for individuals 18 years of age or older.” Remaining coverage criteria updated for clarity and consistency. Added CPT code 83520 to Billing/Coding section. Medical Director review 10/2024.

Transanal Endoscopic Microsurgery (TEMS) (PDF)

Policy Guidelines and References updated. Specialty Matched Consultant Advisory Panel 11/2024. Medical Director review 11/2024.

Transurethral Water Vapor Thermal Therapy and Transurethral Water Jet Ablation (Aquablation) for Benign Prostatic Hyperplasia (PDF)

Minor wording edits to description section. Reference added. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director Review 11/2024.

Urine Culture Testing for Bacteria AHS – G2156 (PDF)

Reviewed per Avalon Q3 2024 CAB. Description, Policy Guidelines and References updated.  No change to policy statement. Medical Director review 10/2024.

Venous and Arterial Thrombosis Risk Testing AHS – M2041 (PDF)

Reviewed by Avalon 3rd Quarter 2024 CAB. Description, Policy Guidelines and References updated. Related Policies section added. Removed Table of Terminology. Changes made to the When Covered section: added "or pulmonary embolism" to coverage criteria 1a, added new coverage criteria 3 that reads "For individuals with a first-degree relative (see Note 2) with a known Factor V Leiden or prothrombin gene G20210A mutation, reimbursement is allowed for genetic testing for the known familial mutation in any of the following situations:  a. For individuals who are considering the use of oral contraceptives. b. For individuals who were assigned female at birth and who are considering hormone replacement therapy. " Added CPT code 0529U to Billing/Coding section, effective 1/1/2025. Medical Director review 10/2024.

Vesicoureteral Reflux, Treatment with Periureteral Bulking Agents (PDF)

Reference added. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.

Wearable Cardioverter Defibrillators (PDF)

References updated. Specialty Matched Consultant Advisory Panel review 10/2024. Medical Director review 10/2024.

Whole Gland Ablative Treatments of Prostate Cancer (PDF)References added. Specialty Matched Consultant Advisory Panel review 11/2024. Medical Director review 11/2024.